Riga Riga, Wandi Oktria, Ahadul Putra, Suryelita Suryelita, Adnan Luthfi Agusta, Okta Suryani, Sri Benti Etika, Bali Yana Fitri, Melindra Mulia, Edi Nasra, Desy Kurniawati, Khairil Arif, Dewi Meliati Agustini
The aim of this research was isolation, structure elucidation, and biological activities of terpenoids from endophytic fungus obtained from G. japonica. An endophytic fungus, Colletotrichum truncatum, was isolated from the roots of G. japonica. C. truncatum was cultivated and extracted to give the crude extract. The crude extract was fractionated using vacuum liquid chromatography followed by separation and purification with column chromatography to obtain a terpenoid derivative (12.8 mg). The compound was characterised for its structure using FT-IR and NMR spectra. Based on spectral analysis, the isolated compound was identified as sydonic acid. The isolated sydonic acid was active against three tested bacterial strains and also demonstrated antioxidant activity with an IC50 value of 76.5 ± 0.93 μg/mL. Interestingly, chemical research on the terpenoid derivative from the fungus C. truncatum associated with G. japonica is first reported herein. © 2025 Informa UK Limited, trading as Taylor & Francis Group.
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, Indonesia; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Departement of Natural Science, Universitas Negeri Padang, Padang, Indonesia; Department of Chemistry, Faculty of Science and Informatics, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
