Trisna Kumala Sari, Rahmida Marlini, Mawardi Mawardi, Romy Dwipa Y. Away, Alizar Ulianas, Radha Afifah, Efwita Astria
Efficient monitoring of blood glucose levels is crucial for diabetes management, yet many existing sensors involve complex fabrication steps or unstable enzymatic components. In this study, a non-enzymatic glucose sensor was fabricated using a simple one-step electrodeposition method using a bimetallic Ag–Au/MWCNT nanocomposite-modified glassy carbon electrode (GCE). Despite the simplicity of the process, SEM–EDS and XRD analyses confirmed the successful and uniform formation of Ag–Au nanoparticles on the MWCNT surface. The resulting Ag–Au/MWCNT/GCE exhibited excellent electrocatalytic activity, a large electroactive surface area, and superior selectivity, stability, and reproducibility. Optimization obtained that the best performance was achieved with an Ag:Au ratio of 1:2 (0.2 mM Ag and 0.4 mM Au) after five electrodeposition cycles. Under these optimized conditions, the sensor showed a linear response to glucose concentrations from 0.1 to 10 mM, with an R2 value of 0.9983 and a detection limit of 0.158 mM. These results highlight the potential of this straightforward electrodeposition strategy for developing simple yet efficient enzyme-free glucose sensors. © The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry 2025.
Department of Chemistry, Faculty of Mathematic and Natural Science, Universitas Negeri Padang, Padang, 25131, Indonesia; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, 501-1193, Japan; Research Center for Polymer Technology, Research Organization for Nanotechnology and Material (ORNM), National Research and Innovation Agency (BRIN), Banten, 15315, Indonesia
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