Prakasini Satapathy, Shubham Chauhan, Shilpa Gaidhane, Ashok Kumar Bishoyi, G. Padma Priya, Karthikeyan Jayabalan, Swati Mishra, Shilpa Sharma, Ganesh Bushi, Muhammed Shabil, Rukshar Syed, Kamal Kundra, Navneet Dev, Sabah Ansar, Sanjit Sah, Quazi Syed Zahiruddin, Shailesh Kumar Samal, Diptismita Jena, Khang Wen Goh
Background: Stroke is a leading cause of morbidity and mortality globally, yet its burden among adolescents and young adults (aged 15–39 years) in South East Asia (SEA) remains understudied. Understanding regional trends and risk factors in this population is critical for effective prevention and management strategies. This study aims to examine stroke trends from 1990 to 2021, focusing on ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in SEA. Methods: Using data from the Global Burden of Disease (GBD) 2021 study, temporal trends in stroke incidence, mortality, and Disability-Adjusted Life Years (DALYs) were analyzed for the age group 15–39 years. Join point regression analysis was employed to identify significant changes in stroke trends, and gender specific patterns were also assessed. Results: Ischemic stroke cases in SEA increased from 28030.85 to 40836.18, with a slight rise in incidence, particularly affecting males aged 30–39, while female mortality dropped by 23.81%. ICH incidence decreased annually by 0.6692%, with significant reductions in DALYs and mortality, especially among younger age groups and females. SAH incidence declined by 0.2142%, accompanied by a notable reduction in female mortality (31.83%). Countries with lower SDI experienced higher stroke incidence and mortality rates, highlighting socio-economic disparities. Geographic analysis revealed the Philippines had the highest rise in ischemic stroke, while most other countries saw declines in ICH and SAH rates. Conclusion: The study highlights significant progress in managing ICH and SAH, especially among younger populations and females. However, ischemic stroke remains a growing challenge, particularly for males, necessitating targeted interventions to reduce the overall stroke burden. Copyright © 2025 Satapathy, Chauhan, Gaidhane, Bishoyi, Priya, Jayabalan, Mishra, Sharma, Bushi, Shabil, Syed, Kundra, Dev, Ansar, Sah, Zahiruddin, Samal, Jena and Goh.
Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, India; Faculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia; Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; One Health Center (COHERD), Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, India; Marwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Gujarat, Rajkot, India; Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Karnataka, Bangalore, India; Department of Chemistry, Sathyabama Institute of Science and Technology, Tamil Nadu, Chennai, India; Department of Pharmacology, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Odisha, Bhubaneswar, India; Department of Pharmacy, Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Punjab, Mohali, India; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India; University of Cyberjaya, Selangor Darul Ehsan, Cyberjaya, Malaysia; University Center for Research and Development, Chandigarh University, Punjab, Mohali, India; Medical Laboratories Techniques Department, AL-Mustaqbal University, Babil, Hillah, Iraq; IES Institute of Pharmacy, IES University, Madhya Pradesh, Bhopal, India; New Delhi Institute of Management, Tughlakabad Institutional Area, New Delhi, India; Department of Dermatology, Graphic Era Deemed to be University, Dehradun, Clement Town, India; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; Department of Pediatrics, Dr. D. Y. Patil Medical College Hospital and Research Center, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Maharashtra, Pimpri, Pune, India; Department of Public Health Dentistry, Dr. D. Y. Patil Medical College Hospital and Research Center, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Maharashtra, Pimpri, Pune, India; Department of Medicine, Korea Universtiy, Seoul, South Korea; South Asia Infant Feeding Research Network (SAIFRN), Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India; Unit of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden; Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India; Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, Indonesia
