Ricvan Dana Nindrea, Milya Novera, Armaita, Long Chiau Ming, Lemmuel Tayo, Yodi Kasinda, Puti Karima Aprila, Nailah Putri Rivani
Background: Tuberculosis (TB) treatment adherence remained a major challenge in high-burden settings, and psychosocial factors such as TB-related stigma and patient motivation may be associated with whether patients completed therapy. Objective: This study examined the relationships between TB-related stigma, patient motivation, and treatment adherence among patients with pulmonary TB in a high TB burden area of West Sumatra, Indonesia. Methods: A cross-sectional survey was conducted from October to December 2025 among adults with drug-sensitive pulmonary TB receiving care in Padang Municipality and Padang Pariaman Regency. The sample comprised 268 participants, selected using a multistage stratified clustered sampling. TB-related stigma (9 items), motivation (4 items), and treatment adherence (4 items) were measured using 4-point Likert scales. The relationships among the variables were analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). Results: The sample was predominantly male (80.2%), with a median age of 42 years and an interquartile range of 36–63, and 72.0% reported a monthly family income below IDR 3.2 million. Motivation showed a positive association with treatment adherence (β = 0.533; t = 9.879; p < 0.001). TB-related stigma showed a strong negative association with motivation (β = −0.817; t = 38.152; p < 0.001) and a negative direct association with adherence (β = −0.443; t = 8.294; p < 0.001). Conclusion: TB-related stigma was associated with poorer treatment adherence both directly and through reduced patient motivation, suggesting the need for stigma-sensitive, motivation-strengthening strategies within routine TB services. © The Author(s) 2026.
Department of Medicine, Faculty of Medicine, Universitas Negeri Padang, Bukittinggi, 26181, Indonesia; Department of Nursing, Faculty of Psychology and Health, Universitas Negeri Padang, Padang, 25131, Indonesia; School of Pharmacy, Sunway University, Sunway City, Malaysia; Mapua School of Health Sciences, Mapua University, Manila, Philippines
