Abdul Hakim Md Yusop, Mohammad Taufiq Al Hakim Bahrudin, Wan Fahmin Faiz Wan Ali, Murni Nazira Sarian, Andril Arafat, Hadi Nur
Biodegradable metals have gained significant attention in the biomaterials community due to their biodegradability and favourable mechanical properties, which are necessary for temporary bone scaffolds. In the past decade, researchers have intensively studied iron (Fe), a type of biodegradable metal known for its high ductility, high tensile strength, and ability to degrade in body fluid. The biocorrosion of Fe-based implants in simulated body fluid (SBF) has been regarded as slow kinetics, while proteins have recently been introduced into SBF to mimic more closely the body's physiological environment. The presence of proteins in SBF changes the biocorrosion behavior of Fe-based implants because the proteins serve as an adsorption medium that changes the surface chemistry at the surfaces of the Fe-based implants. Studies on Fe-protein have primarily focused on surface charges and hydrophilicity factors so far. Accordingly, this review outlines the current developments in studies investigating the in vitro corrosion of Fe-based protein-containing implants. The review also focuses on the factors that orchestrate the protein-Fe surface interactions. © 2024
Materials Research & Consultancy Group (MRCG), Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor, Malaysia; Department of Materials, Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor, Johor Bharu, Malaysia; Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Selangor, Bandar Baru Bangi, Malaysia; Department of Mechanical, Faculty of Engineering, Universitas Negeri Padang, Padang, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia; Center of Advanced Materials for Renewable Energy (CAMRY), Universitas Negeri Malang, Malang, Indonesia
