Himanshu Pandey, Pallavi Pandey, Vikash Jakhmola, Amit Semwal, Mahamedha Deorari, Arif Nur Muhammad Ansori, Rahadian Zainul
Nipah virus (NiV) continues to remain a significant threat to health of the public, characterized by its ability to cause respiratory and neurological complications. The World Health Organization (WHO) has identified NiV as a priority disease for its R and D Blueprint. However, despite extensive research efforts, specific antiviral therapies for NiV infection are currently unavailable. This highlights the crucial need to focus on supportive care for patients affected by the NiV. Therapies Prompt medical attention, including mechanical ventilation and intensive care, is crucial in case of NiV infection. Preventive measures such as avoiding consumption of raw date palm sap and implementing control of infection practices, gives a major role in halting the spread of NiV. This review provides a comprehensive overview of NiV, including its unique characteristics, clinical manifestations, diagnostic methods, treatment strategies, and preventive measures. The article also provides details on vaccines currently undergoing clinical trials, including ChAdOx1, PHV02, mRNA-1215, HeV-sG-V, and CD40.NiV. In addition, it highlights that the m102.4 monoclonal antibody and nucleotide analogue remdesivir has shown effective in the Non-Human Primate (NHP) model was also reviewed. © The Author(s) 2024.
Department of Pharmaceutical Chemistry, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Prem Nagar, Uttarakhand, Dehradun, India; College of Pharmacy, Shivalik Campus. Uttarakhand, Dehradun, India; Department of Pharmacognosy and Phytochemistry, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Prem Nagar, Uttarakhand, Dehradun, India; Postgraduate School, Universitas Airlangga, Surabaya, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Indonesia; Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Indonesia
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock