Saad Bakrim, Naoufal El Hachlafi, Asaad Khalid, Ashraf N. Abdalla, Nasreddine El Omari, Sara Aboulaghras, Ashraf M. Sakran, Khang Wen Goh, Long Chiau Ming, Pakhrur Razi, Abdelhakim Bouyahya
Colorectal cancer (CRC) is one of the most significant forms of human cancer. It is characterized by its heterogeneity because several molecular factors are involved in contiguity and can link it to others without having a linear correlation. Among the factors influencing tumor transformation in CRC, transforming growth factor-beta (TGF-β) plays a key promoter role. This factor is associated with human colorectal tumors with a very high prognosis: it increases the survival, invasion, and metastasis of CRC cells, thus functioning as an oncogene. The inhibition of this factor can constitute a major therapeutic route for CRC treatment. Various chemical drugs including synthetic molecules and biotherapies have been developed as TGF-β inhibitors. Moreover, the scientific community has recently shown a major interest in screening natural drugs inhibiting TGF-β in CRC. In this context, we carried out this review article using computerized databases, such as PubMed, Google Scholar, Springer Link, Science Direct, Cochrane Library, Embase, Web of Science, and Scopus, to highlight the molecular mechanism of TGF-β in CRC induction and progression and current advances in the pharmacodynamic effects of natural bioactive substances targeting TGF-β in CRC. © 2024 The Authors
Geo-Bio-Environment Engineering and Innovation Laboratory, Molecular Engineering, Biotechnology and Innovation Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir, 80000, Morocco; Microbial Biotechnology and Bioactive Molecules Laboratory, Sciences and Technologies Faculty, Sidi Mohmed Ben Abdellah University, P.O.Box-2002, Imouzzer Road, Fez, Morocco; Health Research Center, Jazan University, P.O. Box: 114, Jazan, 45142, Saudi Arabia; Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia; High Institute of Nursing Professions and Health Techniques of Tetouan, Tetouan, Morocco; Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, 10106, Morocco; Department of Anatomy, Faculty of Medicine, Umm Alqura University, Makkah, 21955, Saudi Arabia; Faculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia; School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia; Center of Disaster Monitoring and Earth Observation, Universitas Negeri Padang, Padang, Indonesia; Equal contribution in this work.
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