Rahadian Zainul, Arif Nur Muhammad Ansori, Ahmad Affan Ali Murtadlo, Teguh Hari Sucipto, Viol Dhea Kharisma, Muhammad Hermawan Widyananda, Bayyinatul Muchtaromah, Amaq Fadholly, Muhammad Khaliim Jati Kusala, Vikash Jakhmola, Maksim Rebezov, Sukma Sahadewa, Putu Angga Wiradana
Dengue fever, caused by the dengue virus, is a significant global health concern, with millions of cases reported annually. The absence of specific antiviral treatments or effective preventive measures has fuelled the urgent need for a dengue vaccine. This provides a comprehensive review of the development of a dengue vaccine, summarizing the major milestones, challenges encountered, and recent advancements in this field. This study explores various vaccine strategies employed, including live attenuated vaccines, inactivated vaccines, recombinant subunit vaccines, and viral vector-based vaccines. In addition, the manuscript discusses the clinical trials conducted to evaluate the safety and efficacy of these vaccine candidates. © 2024, Sami Publishing Company. All rights reserved.
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, Indonesia; Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, Indonesia; Postgraduate School, Universitas Airlangga, Surabaya, Indonesia; Generasi Biologi Indonesia Foundation, Gresik, Indonesia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India; European Virus Bioinformatics Center, Jena, Germany; Division of Research and Development, Jalan Tengah, Pasuruan, India; Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia; Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, Indonesia; Master Program of Biology, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia; School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia; Research Center for Veterinary Sciences, National Research and Innovation Agency, Bogor, Indonesia; Department of Scientific Research, Ural State Agrarian University, Yekaterinburg, Russian Federation; Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, Russian Federation; Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, Surabaya, Indonesia; Research Group of Biological Health, Study Program of Biology, Faculty of Health and Science, Universitas Dhyana Pura, Bali, Indonesia
