Dora Dayu Rahma Turista, Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Karina Ahmedovna Kardanova, Islam Ruslanovich Aslanov, Ibragim Muhadinovich Dotkulov, Azret Zamirovich Apshev, Amir Albertovich Dokshukin, Maksim Rebezov, Vikash Jakhmola, Md. Emdad Ullah, Rahadian Zainul
SARS-CoV-2 has caused a prolonged COVID-19 pandemic since the end of December 2019 and is still ongoing now. Bioactive compounds can be used as drugs to treat infectious diseases. This study aims to determine C. alata as a drug candidate for COVID-19 through its inhibitory activity to Mpro SARS-CoV-2 in silico. Cassia alata bioactive compounds have the potential to be used as a candidate for anti-SARS-CoV-2 supported by the result of drug-likeness, ADMET, pharmacokinetics, binding affinity, and antiviral activity prediction. Further research needs to be carried out to make C. alata a drug for COVID-19. © RJPT All right reserved.
Department of Biology Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, Indonesia; Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia; Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, Indonesia; Postgraduate School, Universitas Airlangga, Surabaya, Indonesia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India; Medical Faculty, Kabardino-Balkarian State University, Nalchik, Russian Federation; Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, Russian Federation; Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, Russian Federation; Department of Chemistry, Mississippi State University, Mississippi, United States; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, Indonesia; Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, Indonesia
