Arif Nur Muhammad Ansori, Ahmaf Affan Ali Murtadlo, Viol Dhea Kharisma, Bayyinatul Muchtaromah, Muhammad Badrut Tamam, Dora Dayu Rahma Turista, Imam Rosadi, Vikash Jakhmola, Tarun Parashar, Taru Saklani, Maksim Rebezov, Rahadian Zainul, Hery Purnobasuki, Amaq Fadholly, Muhammad Kusala
The global health landscape has seen an upsurge in viral diseases, underlining the urgency for novel antiviral therapies. This mini-review illuminates the potential antiviral capabilities of gamma-mangostin, a xanthone derivative derived from the pericarp of the Garcinia mangostana fruit. Gamma-mangostin's mechanisms of action are multifaceted, displaying inhibitory effects on viral entry into host cells, disrupting essential cell signalling pathways for viral replication, and enhancing the host's immune response via antiviral cytokine stimulation. This compound has demonstrated significant in vitro efficacy against numerous viruses, including Influenza A virus, Herpes simplex virus, and Hepatitis C virus, and emerging preliminary research suggests potential utility against SARS-CoV-2. Its broad-spectrum antiviral properties and low cytotoxicity earmark gamma-mangostin as a promising candidate for future antiviral agent development. However, rigorous investigation is required to determine its pharmacokinetics, bioavailability, and safety profile. With the escalating burden of viral diseases, gamma-mangostin could represent an important tool in the armamentarium for disease management, contingent upon further study. This review provides an overview of current research into gamma-mangostin's antiviral potential and the challenges to its therapeutic development. © 2024 by SPC.
Postgraduate School, Universitas Airlangga, Surabaya, Indonesia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India; Generasi Biologi Indonesia Foundation, Gresik, Indonesia; Division of Research and Development, CV Jalan Tengah, Pasuruan, Indonesia; European Virus Bioinformatics Center, Jena, Germany; Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia; Department of Biology, Faculty of Science, Technology and Education, Universitas Muhammadiyah Lamongan, Lamongan, Indonesia; Department of Biology Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, Indonesia; Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, Russian Federation; Department of Scientific Research, Ural State Agrarian University, Yekaterinburg, Russian Federation; Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, Indonesia; Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia; School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia; Research Center for Veterinary Sciences, National Research and Innovation Agency, Bogor, Indonesia
