Rahadian Zainul, Dony Novaliendry, Agariadne Dwinggo Samala, Budhi Oktavia, Cheng-Hong Yang, Devi Purnamasari, Mirella Fonda Maahury, Rollando, Rismi Verawati, Muhammad Arya Ghifari, Muhammad Thoriq Albari, Muhammmad Raffi Ghifari, Putri Azhari, Riso Sari Mandeli
This research aims to study the interaction between astragaloside, astragalus plant extract, and adrenergic receptor alpha-2 as a regulation of sympathetic nervous system activity. The research methods used include the use of Pymol, Pyrex, Protein Plus, and Lipinski Rule software for molecular analysis and protein structure characterization. The results showed that astragaloside had a binding affinity of-6.4. In addition, RMSD was found to be 0, 2.515, and 2.703, which indicated the success of astragaloside in interacting with adrenergic receptor alpha-2. Analysis using Protein Plus showed an interaction between astragaloside and adrenergic receptor alpha-2. Lipinski analysis showed that astragaloside has a mass of 618, 10 hydrogen bond donors, 17 hydrogen bond recipients, a logP of-0.0197, and a molar reactivity of 127.710. These findings provide further understanding of the mechanism of astragaloside's interaction with adrenergic receptor alpha-2, which could potentially regulate sympathetic nervous system activity. This study contributes to the therapies development based on astragalus plant extracts for effective regulation of sympathetic nervous system function. © 2023 by SPC (Sami Publishing Company).
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, West Sumatra, Padang, Indonesia; Department of Electronics Engineering, Faculty of Engineering, Universitas Negeri, Padang, Indonesia; Electronic Department, National Kaohsiung University of Science and Technology, Kaohsing, Taiwan; Department of Radiology, Faculty Health, Universitas Awal Bros, Indonesia; Department of Chemistry, Faculty of Mathemetics and Natural Sciences, Pattimura University, Indonesia; Department of Pharmacy Program, Faculty of Health Sciences, Universitas Ma Chung, Malang, Indonesia; Department of Information Technology, Faculty of Computer Sciences, Universitas Brawijaya, East Java, Malang, Indonesia; Department of Agricultural Technology, Faculty of Agricultural Technology, Universitas Andalas, Padang, Indonesia; Department of Environmental Science, Postgraduate Programme, Universitas Negeri Padang, West Sumatera, Padang, Indonesia
