Syeftyan Muhammad Ali Hamami, Michelle Fai, Ahmad Fariduddin Aththar, M. Nizam Zulfi Zakaria, Viol Dhea Kharisma, Ahmad Affan Ali Murtadlo, Muhammad Badrut Tamam, Vikash Jakhmola, Muhammad Hermawan Widyananda, Dora Dayu Rahma Turista, Maksim Rebezov, Nikolai Maksimiuk, Nataliya Kulmakova, Evgeniya Latynina, A.N.M. Ansori, Rahadian Zainul, Riso Sari Mandeli, Devi Purnamasari, Oski Illiandri, Khoirun Nisyak, Ernarisa Fitri
Conventional chemotherapy substances are associated with mild to severe side effects that affect both healthy and cancer cells. It is presumed to improve therapeutic efficacy in coexistence reducing chemotherapy’s side effects. Fucoidan is an anticancer bioactive compound derived from Sargassum sp. that has low cytotoxic activity. The purpose of this study was to explore the effectiveness of anticancer activities of fucoidan from Sargassum sp. against breast cancer then analyze the suitability of nano transdermal patch of fucoidan and blueprint the long-term research design of nano transdermal patch as a chemoprevention agent in the chemotherapeutic management of breast cancer. This research was performed through a literature study and in silico study by imposing carbonic anhydrase IX (CA IX) as a marker of hypoxia and metastatic state of cancer cells. The results showed that the fucoidan from Sargassum sp. effectively induced apoptosis and prevented metastasis of breast cancer cells through the Bcl-2, Bcl-w, and bad pathways. Fucoidan, in addition, was predicted to inhibit CA IX by Glu4 Glu5, Leu7, Pro8, and Asp6 residues. Therefore, the delivery of fucoidan is favored to have a local effect on the site of breast cancer cells by nano transdermal patch preparations using fucoidan nanoparticle polymer. Further nano transdermal patch development as a treatment for breast cancer is suggested through the stages of formulation optimization, optimum formula activity testing, patent filing, and distribution in health services. © 2022 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Department of Biology, Faculty of Mathematics and Life Sciences, Universitas Brawijaya, Malang, Indonesia; Department of Biology, Faculty of Scienceand Technology, Universitas Airlangga, Surabaya, Indonesia; Division of Molecular Biology and Genetics, Generasi Biology Indonesia Foundation, Gresik, Indonesia; Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, Indonesia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India; Department of Biology Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, Indonesia; Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, Russian Federation; Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, Russian Federation; Department of Scientific Research, Russian State Agrarian University Moscow Timiryazev Agricultural Academy, Moscow, Russian Federation; Institute of Medical Education, Yaroslav-the-Wise Novgorod State University, Velikiy Novgorod, Russian Federation; Department of Veterinary Medicine, Russian State Agrarian University, Moscow Timiryazev Agricultural Academy, Moscow, Russian Federation; Professor Nidom Foundation, Surabaya, Indonesia; Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, Indonesia; Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Indonesia; Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, Indonesia; Department of Biomedicine, School ofMedicine, Lambung Mangkurat University, Banjarmasin, Indonesia; Department of Pharmacy, Faculty of Public Health, Universitas Anwar Medika, Sidoarjo, Indonesia; Department of Chemistry, Faculty of Mathematicsand Natural Sciences, Universita sAndalas, Padang, Indonesia
