Aldi Tamara Rahman, Rafia, Aiken Jethro, Putra Santoso, Viol Dhea Kharisma, Ahmad Affan Ali Murtadlo, Devi Purnamasari, Nunuk Hariani Soekamto, A.N.M. Ansori, Kuswati, Riso Sari Mandeli, Kawther Ameen Muhammed Saeed Aledresi, Nur Farhana Mohd Yusof, Vikash Jakhmola, Maksim Rebezov, Rahadian Zainul, Kiran Dobhal, Tarun Parashar, Muhammad Arya Ghifari, Deffi Ayu Puspito Sari
Cancer is one of the diseases that is the highest cause of death in humans. Most human cancer cells are formed as a result of over-expression of anti-apoptotic proteins. Thus, the activation of these proteins can inhibit pro-apoptotic proteins, then apoptosis will be inhibited so that other apoptotic pathways need to be activated to prevent cancer cells from developing. Current cancer treatments, such as chemotherapy using synthetic compounds, have various side effects, so research on natural based therapies can be used as an alternative in cancer treatment. Curcuma sumatrana is one of the plants of the Zingiberaceae family which is an endemic plant from Sumatra which is found along the Bukit Barisan. The research was carried out in silico by analyzing the potential bioactivity of the compounds, testing the bioavailability, toxicity, and molecular docking of the bioactive compounds from the ethanol extract of the rhizome of C. sumatrana which had been previously identified through gas chromatography-mass spectroscopy (GC-MS) analysis. The results obtained that the compound 9-Acetyl-S-octahydrophenanthrene and 3-Oxo-androsta-1,4-dien-17.beta.-spiro-2'-3'-oxo-oxetanecontained in C. sumatrana has the potential to be developed as an anticancer where the compound has good bioavailability value and is not toxic and potentially can trigger apoptosis. However, the results of this study need to be analyzed further with an in vitro or in vivo approach. © 2022 Phcogj.Com. This is an open- access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Department of Biology, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia; Department of Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia; Division of Molecular Biology and Genetics, Generasi Biology Indonesia Foundation, Gresik, Indonesia; Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, Indonesia; Chemistry Department, Faculty of Mathematics and Natural Science, Hasanuddin University, Indonesia; Professor Nidom Foundation, Surabaya, Indonesia; Biology Education Study Program, Faculty ofTeacher Training and Education, Jember University, Indonesia; Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, Indonesia; Biochemistry Department, Hawler Medical University, Iraqi Kurdistan, Arbil Governorate, Erbil, Iraq; College of Engineering (Chemical), Universiti Teknologi MARA (UiTM), Jalan Purnama, Bandar Seri Alam, Masai, Johor, Malaysia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India; Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, Russian Federation; Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, Russian Federation; Department of Scientific Research, Russian State Agrarian University, Moscow, Russian Federation; Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, Indonesia; Department of Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, Indonesia; Environmental Engineering Program Study, Faculty of Engineering and Computer Sciences, Universitas Bakrie, Jakarta, Indonesia
