Ichwan Baihaki, Beti Ernawati Dewi, Viol Dhea Kharisma, Ahmad Affan Ali Murtadlo, Muhammad Badrut Tamam, Devi Purnamasari, Nunuk Hariani Soekamto, A.N.M. Ansori, Kuswati, Riso Sari Mandeli, Kawther Ameen Muhammed Saeed Aledresi, Nur Farhana Mohd Yusof, Vikash Jakhmola, Maksim Rebezov, Pavel Burkov, Marina Derkho, Pavel Scherbakov, Rahadian Zainul, Muhammad Raffi Ghifari, Asmi Citra Malina A.R. Tasakka, Tengku Siti Hajar Haryuna
Dengue is a major public health threat worldwide, affecting approximately 3 billion people. More than 100 countries in the world located in tropical and subtropical areas, there are at least 100 to 400 million people infected with the dengue virus which causes dengue hemorrhagic fever (DHF). Soluble Non Structural Protein (sNS1) DENV is a soluble NS1 protein that is secreted and found in the serum of patients during acute infection. Because of its presence early in infection, sNS1 is used as a diagnostic indicator of acute dengue infection. NS1 can directly activate platelets through TLR4 and can further increase platelet aggregation, endothelial cell adhesion, and phagocytosis by macrophages that can cause thrombocytopenia so that high sNS1 levels are associated with disease severity. From the results of the study showed p <0.05. This indicates that there is a correlation between the presence of NS1 and the severity of dengue infection. © 2022 Phcogj.Com.
Master Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia-RSUPN Cipto Mangunkusumo, Jakarta, Indonesia; Infectious Disease and Immunology Cluster, Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia; Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, Indonesia; Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, Indonesia; Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, Indonesia; Chemistry Department, Faculty of Mathematics and Natural Science, Hasanuddin University, Indonesia; Professor Nidom Foundation, Surabaya, Indonesia; Biology Education Study Program, Faculty ofTeacher Training and Education, Jember University, Indonesia; Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, Indonesia; Biochemistry Department, Hawler Medical University, Arbil Governorate, Iraqi Kurdistan, Erbil, Iraq; College of Engineering (Chemical), Universiti Teknologi MARA (UiTM), Jalan Purnama, Bandar Seri Alam, Johor, Masai, Malaysia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India; Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, Russian Federation; Faculty of Biotechnology and Food Engineering, UralState AgrarianUniversity, Yekaterinburg, Russian Federation; Department of Scientific Research, Russian State Agrarian University, Moscow, Russian Federation; Institute of Veterinary Medicine, South Ural State Agrarian University, Troitsk, Russian Federation; Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, Indonesia; Department of Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, Indonesia; Faculty of Marine Science and Fisheries, Universitas Hasanuddin, Makassar, Indonesia; Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
