Abellisa, Lestari Sukma Dinullah, Fikri Alsidik Ajis
Wound healing is a significant challenge in both human and veterinary medicine, particularly in cases involving trauma, infection, or chronic tissue damage. Platelet-rich plasma (PRP), a product derived from the patient's own blood and enriched with growth factors and cytokines, has gained interest for its potential to promote regeneration and enhance healing. The present study aimed to evaluate current evidence on the application of PRP and its derivatives in wound healing, with a specific focus on veterinary animal models, and to identify key mechanisms, therapeutic outcomes, and existing knowledge gaps. While the present study highlighted veterinary applications, the included studies also consisted of rodent models, in vitro experiments, and human cell lines, providing broader mechanistic insights. A structured narrative review was conducted using 25 peer-reviewed articles published between 2024 and 2025. The selected studies included controlled trials, in vitro experiments, systematic reviews, and concept papers on PRP, platelet-rich fibrin, plasma rich in growth factors, and emerging formulations such as induced pluripotent stem cell-derived platelets and protein-rich PRP matrices. Key data related to study design, subjects, intervention types, outcomes, and theoretical frameworks were extracted and analyzed. All studies confirmed the positive role of PRP in promoting angiogenesis, collagen formation, epithelialization, and inflammation modulation. Evidence from veterinary models, including feline trauma cases and animal-derived PRP, supported the clinical applicability of PRP in wound healing. Several studies have demonstrated that the PRP approach is a valuable and effective treatment method in clinical practice, applicable to patients and animals. The PRP proved to be an efficacious intervention for cutaneous wounds, including surgical wounds, traumatic injuries, and chronic ulcers. However, differences in PRP preparation methods and outcome assessment criteria hinder direct comparisons across studies. Recent findings indicated new mechanisms involving telocytes and the regulation of vascular genes. It has been indicated that PRP and its derivatives are promising biological therapies for improving wound healing in veterinary practice. © The Author(s) 2026. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
Department of Veterinary Medicine, Faculty of Medicine, Universitas Negeri Padang, Bukittinggi, 26181, Indonesia; School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia
