Shafiyah Pondi, Jon Efendi, Ho Chin Siong, Lai Sin Yuan, Sheela Chandren, Hadi Nur
The drug-delivery field has been an attractive as well as challenging area for research. With the emerging of new formulated drugs and pharmaceutical compounds, development of good drug-delivery system (DDS) is crucially required. This study aims to utilize albumin as the drug template in silica/albumin/drug (S/A/D) system. Prior to designing this system, the interaction between silica and albumin was investigated. It is hypothesized that high interaction between silica and albumin may result in slower drug release over time, which is preferred for a good DDS. Silica and albumin (S/A) materials were prepared by using fumed silica and tetraethyl orthosilicate (TEOS) as the silica precursors. Three different S/A samples were prepared; fumed silica with albumin (FS/A), fumed silica with pre-treated albumin by sodium borohydrate (FS/A-N), and silica sol (TEOS) with albumin (SS/A). In-vitro release of albumin in phosphate buffer solution (pH 7) was carried out to examine the interaction between albumin and silica. The concentration of albumin was detected at 280 nm by UV-visible spectrophotometer. All samples were characterized by diffuse reflectance-UV-visible spectrophotometer (DR-UV), Fourier transform infrared spectrophotometer (FTIR) dan thermogravimetric-differential thermal analysis (TG-DTA). DR-UV results show that SS/A exhibited the lowest absorption intensity at 280 nm, which indicates better interaction between silica and albumin. This result was supported by the presence of Si-O stretching band of silanol at 952 cm-1 from the FTIR spectrum. Release study of albumin demonstrated that the release of albumin from SS/A was slowest compared to those of FS/A and FS/A-N. © 2014 Penerbit UTM Press. All rights reserved.
Ibnu Sina Institute for Fundamental Science Studies, Universiti Teknologi Malaysia, UTM, 81310 Johor Bahru, Johor, Malaysia; Department of Chemistry, Universitas Negeri Padang, Air Tawar, Padang 25131, Jln. Prof. Dr. Hamka, Indonesia; Low Carbon Asia Research Center, Universiti Teknologi Malaysia, UTM, 81310 Johor Bahru, Johor, Malaysia; Department of Physics, Institut Sains dan Teknologi Nasional, Jagakarsa, Jakarta Selatan 12640, Jl. Moh. Kahfi II, Indonesia
