Sugiharto, Adi Pranoto, Nurul Ihsan, Hanna Goenawan, Desiana Merawati, Purwo Sri Rejeki, Gigih Siantoro, Fikri Sasongko Widyatama, Prayogi Dwina Angga
Objectives: A well-structured, regular, and programmed physical exercise regimen is believed to be an effective physiological modulator for preventing the dysfunction of myonectin and visfatin secretion. Therefore, this study aims to analyze the physiological regulation of moderate-intensity programmed exercise in improving myonectin and visfatin biomarkers in obese women. Methods: The study involved 30 physically healthy obese women, nonathletes, selected based on predetermined criteria, who voluntarily agreed to participate. They were then divided into two groups: a control group (CRT; n=15) and a programmed exercise group (ART; n=15). The exercise program lasted for 8 weeks, with a frequency of 5 times per week at moderate intensity. Metabolic performance was analyzed using the myonectin and visfatin biomarkers with the Sandwich-ELISA method. Data analysis was conducted using parametric paired sample t-tests and independent sample t-tests at a 5% significance level. Results: The study results showed a significant increase in myonectin secretion and a decrease in visfatin secretion (p≤0.05) after 8 weeks of programmed exercise, demonstrated by an increase in myonectin of 97.85pg/mL and a decrease in visfatin of 0.05ng/mL. Conversely, in the control group, myonectin decreased by 3.04pg/mL, and visfatin increased by 0.03ng/mL. Conclusions: These findings confirm that an 8-week programmed exercise regimen can improve the secretion of myonectin and visfatin biomarkers, thereby enhancing metabolic performance in obese women. Thus, myonectin and visfatin biomarkers induced by programmed exercise serve as modulators for enhancing metabolic performance in obese women. © 2025 Walter de Gruyter GmbH, Berlin/Boston.
Department of Sport Science, Faculty of Sport Science, Universitas Negeri Malang, Malang, Indonesia; Department of Sports Coaching Education, Faculty of Sports and Health Science, Universitas Negeri Surabaya, Surabaya, Indonesia; Sport and Exercise Research Center, Universitas Negeri Surabaya, Surabaya, Indonesia; Faculty of Sports Sciences, Universitas Negeri Padang, Padang, Indonesia; Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Physiology Division, Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Elementary Education, Faculty of Teacher Training and Education, Universitas Mataram, Mataram, Indonesia
