Ranjit Sah, Prakasini Satapathy, Abhay M. Gaidhane, Nasir Vadia, Soumya V. Menon, Kattela Chennakesavulu, Rajashree Panigrahi, Ganesh Bushi, Mahendra Singh, Sanjit Sah, Rachana Mehta, Awakash Turkar, S. Govinda Rao, Khang Wen Goh, Muhammed Shabil, Andrea G. Rodriguez-Morales, Tania do Socorro Souza Chaves, Pasesa Quispe-Torrez, Rodrigo Nogueira Angerami, Bijaya Kumar Padhi, Alfonso J. Rodriguez-Morales
Oropouche virus (OROV), an emerging arbovirus, poses a significant public health concern in tropical and subtropical regions of Latin America, as well as in other parts of the world, with imported cases reported in North America and Europe. While OROV is primarily associated with acute febrile illness, especially emerging evidence suggests it may cause neurological complications, though these remain understudied. This systematic review and meta-analysis aim to estimate the prevalence of neurological manifestations in OROV infections. Following the PRISMA 2020 guidelines, a systematic literature search was conducted across PubMed, Web of Science, and Embase up to January 25, 2025, and registered in PROSPERO (Registration ID: CRD42025634617). Nested Knowledge software was employed for the screening and data extraction processes. Data extraction and quality assessment were performed using a modified version of the Newcastle-Ottawa Scale. A meta-analysis was conducted using R software to estimate the pooled prevalence rates of neurological manifestations, with heterogeneity assessed using the I² statistic. Sensitivity analyses and publication bias assessments were also performed. Ten studies from Brazil, Peru, and Colombia were included, encompassing a total of 2872 patients. The pooled prevalence of neurological symptoms was high, with headache (89.16%), myalgia (70.71%), and eye pain (52.87%) being the most common. Other symptoms included arthralgia (56.5%), back pain (46.1%), and nausea (43.3%). Significant heterogeneity was observed across studies, likely due to variations in geography and diagnostic methods. Sensitivity analyses confirmed the robustness of the findings. Neurological manifestations are prevalent in OROV infections, with headache, myalgia, and eye pain being the most frequent. The clinical overlap with other arboviruses complicates diagnosis, underscoring the need for improved diagnostic tools and surveillance of neurological syndromes associated with arboviruses in endemic regions and newly emerging areas with recent circulation of the virus. To improve generalizability, future research should broaden geographic analyses and concentrate on longitudinal and standardized studies to better understand the temporal dynamics of symptoms. © 2025 Wiley Periodicals LLC.
BMC South, Boston Medical Center Health System, Boston, MA, United States; Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Jawaharlal Nehru Medical College, and Global Health Academy, School of Epidemiology and Public Health. Datta Meghe Institute of Higher Education, Wardha, India; Marwadi University Research Center, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Marwadi University, Gujarat, Rajkot, India; Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Karnataka, Bangalore, India; Department of Chemistry, Sathyabama Institute of Science and Technology, Tamil Nadu, Chennai, India; Department of Microbiology, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to be University), Odisha, Bhubaneswar, India; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India; Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, India; Graphic Era Hill University, Dehradun, India; Department of Paediatrics, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Maharashtra, Pune, India; Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth (Deemed-to-be-University), Maharashtra, Pune, India; Department of Medicine, Korea University, Seoul, South Korea; Dr Lal Path Labs - Nepal, Kathmandu, Nepal; Clinical Microbiology, RDC, Manav Rachna International Institute of Research and Studies, Haryana, Faridabad, India; Centre Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Punjab, Rajpura, India; Department of Data Science, Gokaraju Rangaraju Institute of Engineering and Technology, Telangana, Hyderabad, India; Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, Indonesia; University Center for Research and Development, Chandigarh University, Punjab, Mohali, India; Unidad Procedimientos, Policlínico Neurología, Centro de Referencia de Salud Dr. Salvador Allende Gossens, Santiago de Chile, Chile; Universidade Federal do Pará, Belém, Brazil; Dr. Radamés Nardini Clinical Hospital – ABC Santo André, SP, São Paulo, Brazil; Núcleo de Vigilância Epidemiológica, Seção de Epidemiologia Hospitalar, Hospital de Clínicas, Universidade Estadual de Campinas, SP, Campinas, Brazil; Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Faculty of Health Sciences, Universidad Científica del Sur, Lima, Peru; Grupo de Investigación Biomedicina, Facultad de Medicina, Fundación Universitaria Autónoma de las Américas-Institución Universitaria Visión de las Américas, Risaralda, Pereira, Colombia
