Hamdani, Anton Komaini, Junian Cahyanto Wibawa, Joseph Lobo, Ainun Zulfikar Rizki, Alvin Afandi, Dwi Lorry Juniarisca, Bambang Ferianto Tjahyo Kuntjoro, Muchamad Arif Al Ardha, Novadri Ayubi
The goal of this research is to examine the benefits of physical activity for increasing mechanistic target of rapamycin (mTOR) as a trigger for muscle hypertrophy through the process of cell proliferation from a physiological point of view. In this systematic review investigation, literature databases such as MEDLINE-Pubmed, Web of Science, Scopus, and Science Direct were searched. Papers that discussed physical exercise, the mechanis-tic target of rapamycin (mTOR), and were published during the previous five years met the inclusion criteria. 96 published publications were located using the Science Direct, Pubmed, and Web of Science databases. Seven papers that satisfied the inclusion criteria were ultimately chosen and reviewed for this systematic review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used in this study to as-sess the standard operating procedures. According to this systematic study, exercise has been proven to raise mTOR. Re-sistance training has a higher potential to increase mTOR than aerobic training. Exercise has been shown to raise the phosphorylation of mTOR in cells. Evidence suggests that an increase in mTOR after physical exercise can trigger muscle hypertrophy through the process of cell proliferation. Physical exercise is obvious-ly a good effort in maintaining muscle to avoid the mechanism of muscle atrophy, espe-cially related to age and several metabolic syndrome diseases. © 2025 by the authors.
Universitas Negeri Surabaya, Surabaya, Indonesia; Universitas Negeri Padang, Padang, Indonesia; STKIP PGRI Trenggalek, Trenggalek, Indonesia; Bulacan State University, Malolos, Philippines
